However, as pinpointed by Kapur and Remington in 1996 [1], these molecules have, by definition, a fixed ratio of affinities for their different targets, and, unlike a cocktail of distinct active principles, do not permit to modulate each of them in an independent manner.
Presynaptic NPS receptors have been located to terminals of LA principle neurons and were shown to modulate glutamatergic transmission onto neurons of the intercalated cell mass [28].
Together, data obtained from experimental animals and from human studies indicate that appropriate nutrition is a powerful but in principle very safe immunorestorative means to modulate immunosenescence.
Nevertheless, the same effect differential codon usage has on the overall translation speed of a protein is also playing a role locally: in principle it would be possible to modulate the translation speed of different regions of a protein chain choosing among the codons available for the amino acids required in these regions (see [ 15] and references herein).
Peptides released at the CI tract region thus appear well suited to modulate interneurons, which in principle could provide an effective means to achieve wide ranging effects on different (interlinked) neuronal networks [114].
Thus, antioxidant principles from natural sources can provide a multifaceted approach to modulate oxidative imbalance found in human degenerative diseases.
With respect to the patient's physical condition, the use of reinforcing and reducing acupuncture information to modulate the laser beam, which adheres to the principles of TCM dialectical therapy, follows the TCM acupuncture principle of treating deficiency syndrome.
Our work fulfills the proof of principle that pharmacological compounds like quercetin can target select members of the J protein family to modulate their cellular behavior.
We are looking for a principle that would, in absence of overwhelming imprinted drives, provide natural behaviour preferences that might contribute to modulate pre-imprinted drives or help constituting generic homeostatic variables.
The invariance principle demonstrated above for metabolic reactions indicates that there are infinitely many ways for the cell to modulate enzyme levels to bring substrate from a particular initial concentration to a particular final concentration in a given time interval.
