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A single mutation (Ile87Ala) in the same CD loop region of the Epstein-Barr virus IL-10 (ebvIL-10) also reduces IL-10R1 binding affinity, suggesting that ebvIL-10 and 9D7Fab use similar allosteric mechanisms to modulate IL-10R1 affinity and biological activity.
Thus, our results suggest that MSC display different mechanisms to modulate the functional profile of macrophages.
Rather, HN may evoke other unidentified mechanisms to modulate NEP expression.
In order to optimize growth and reproduction and to minimize photodamage, phytoplankton has developed a number of mechanisms to modulate the rate of photosynthesis in situ.
These results support the notion that the bacterial cell is equipped with active mechanisms to modulate acquisition of new DNA in different genomic positions.
Together, these results demonstrate that Nef has evolved independent mechanisms to modulate IS function and that the reduction of early TCR transmission is primarily mediated by interference of Nef with actin remodeling and protein recruitment to the IS.
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Meanwhile, the interaction between atmospheric gravity waves (AGWs) and ionospheric plasma has long been considered as a plausible mechanism to modulate the ionosphere (Hines 1960).
Taken together, these results further highlight the importance of the tetramer formation in PKM2 activation and suggest that the regulation of PKM2 oligomerization may be a general mechanism to modulate PKM2 activity.
First, PIM1 is a phosphokinase and phosphorylation of components in the RLR pathways is a common mechanism to modulate the pathway (Bachmann and Moroy, 2005; Quicke et al., 2017; Ivashkiv and Donlin, 2014).
We identify common design principals that highlight how the spatial organization of signal transduction circuits can be used as a fundamental control mechanism to modulate system outputs in vivo.
Thus, phosphorylation is probably a common cellular mechanism to modulate HCN channel activity.
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