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The V-ATPase itself can act as a pH sensor, interacting with small GTPases in an acidification-dependent manner to modulate vesicular trafficking [3], [54], [55].
These receptors work in a coordinated manner to modulate the responses of neurons to neurotrophins.
Potentially, many microRNAs from this cluster might act on various mRNA targets in a coordinated manner to modulate dendritogenesis and spine morphology.
Acting either in a paracrine manner to modulate the activity of surrounding cells or in an autocrine fashion, cytokines perform a wide variety of functions.
They mediate diverse biological processes, including neuronal morphogenesis, tumor invasion, and bone formation, and act in a coordinated manner to modulate cellular functions.
The regulation of cytokine production by TLR4 is complicated by the ability of certain LPS induced cytokines to act in a paracrine or autocrine manner to modulate cytokine production.
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Whilst some miRNAs are expressed in an androgen-dependent manner, others appear to modulate various aspects of androgen signalling in prostate cancer.
Together, the available data points to the need for development of dual therapeutic strategies that modulate microglia activation to change not only the way microglia interact with the peripheral immune system, but also to modulate the manner in which microglia respond to encounters with α-syn.
Once released, GABA is thought to act in an auto- and para-crine manner on the islet cells to modulate hormone secretion [ 7, 8].
In this manner, T. gondii is able to modulate the innate and adaptative host immune system in order to reduce the immune response rather than its complete inhibition [ 101].
To determine whether LIF acts in a paracrine manner within the developing placenta to modulate the invasive capacity of trophoblast, we examined the effects of LIF on primary trophoblast cells derived from first trimester decidua, with a focus on their adhesive capacity, expression of adhesion molecules and production of MMPs and TIMPs.
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