Sentence examples for accumulation of inactive from inspiring English sources

Since they found a correlation between drug accumulation and creatinine clearance, the potential that the finding of increased exposure in patients without native NAT2*4 could be due to accumulation of inactive SMX metabolites.

The best inhibitor was found to promote the accumulation of inactive form of MPO-Compound II and has IC50 = 54 nM, demonstrating the successful approach of the drug design.

Neither virus nor protozoa were detected in the treated water, with the exception of measurement of adenovirus genome copies attributed to accumulation of inactive genetic material in hydraulic dead zones.

GSE56 antagonizes p53 function through interaction with its oligomerisation domain, subsequently resulting in the dramatic accumulation of inactive p53 [41] (Figure 5D).

Previously we showed [41] that there was a depletion of active chromatin marks on the mitotic inactive X chromosome in female fibroblast cells of the tammar wallaby, but with no apparent accumulation of inactive histone modifications.

The accumulation of inactive enzymes in nematodes was among the first molecular characteristics of aging identified [ 31].

We hypothesized that the Q1069R substitution impaired ACE trafficking to the cell surface and led to accumulation of catalytically inactive ACE in the cell cytoplasm.

Earlier studies on halorhodopsin from another archaebacterium, Halobacterium halobium, found evidence for a similar type of rundown, due to accumulation of an inactive 13-cis retinal form of the halorhodopsin molecule, which required seconds to recover to the original state [37].

Conclusion: These data provide the first direct evidence that physiological expression of PNPLA3 148M variant causes NAFLD, and that the accumulation of catalytically inactive PNPLA3 on the surfaces of lipid droplets is associated with the accumulation of TG in the liver.

This has important therapeutic ramifications in that pharmacological inhibition of HDACs might be expected to result in the accumulation of the inactive acetylated BCL-6 which can then induce cell-cycle arrest and death of B-cell lymphoma cells.

It has been shown that NAMI-A [ 47] inhibited the invasion and metastasis of cancer cells by arresting them at the G2/M stage and that it is a likely consequence of the accumulation of an inactive phosphorylated form of Cdk1, caused by the lack of Cdc25 phosphatase activity [ 21].