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Using an alternate strategy, we have also demonstrated that the buildup of inactive Bak in response to pIFN- α treatment sensitizes the M14 melanoma cell mitochondria to BH3 peptide-mediated cyt c release.
Using the technique of BH3 profiling developed by Letai and colleagues, we observed that a buildup of inactive Bak in the mitochondria as a consequence of pIFN- α treatment made the M14 melanoma cells more sensitive to VBL-induced cell death (i.e., pIFN- α conditions or primes the cells to death signaling induced by other agents).
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Look through the list of inactive people.
A smile represents a buildup of tension.
Atherosclerosis — the buildup of fats and cholesterol on the artery walls that can lead to stroke and heart disease — is generally considered a problem of modern times, a result of fatty diets and inactive lifestyles.
So a vast buildup of economically strategic installations is occurring.
A buildup of such material is called a spit.
Then there was a buildup of blood behind his knee.
"Otherwise we would have a continuous buildup of materials".
That's behind the big buildup of dynastic wealth".
This prevents a buildup of excess pressure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com