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The aim of this study was to develop and validate a simple technique for a new tidal single breath washout test (SBW) of sulfur hexafluoride (SF6) and helium (He) using an ultrasonic flowmeter (USFM).
Furthermore, the use of 100% oxygen in the nitrogen washout test used in many studies to determine lung volume may induce atelectasis [22], and the effect may be more pronounced in young and preterm infants [23].
See the Additional file 2: Figure S2 for the single breath nitrogen washout test curve.
Additionally, reduced sequential ventilation and airway closure in the prone posture compared with supine posture has been previously shown in dogs with normal lungs by single breath washout test [ 27].
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Small airway disease frequently occurs in chronic lung diseases and may cause ventilation inhomogeneity (VI), which can be assessed by washout tests of inert tracer gas.
Mutko did not address allegations in McLaren's report that he directed so-called washout testing – unofficial internal tests before major competitions to ensure banned substances would not be detectable when doped athletes later gave samples at the event.
McLaren put particular focus on Russia's behaviour before London 2012, pointing out that many athletes were given a cocktail of undetectable steroids by the Russian Anti-Doping Agency before the Games – before being subjected to what he called "washout testing", to ensure they did not test positive at the Olympics.
Currently washout tests are underutilised due to the time and effort required for measurements.
Using the USFM for a modified SBW procedure would eliminate some shortcomings of current tracer gas washout tests in clinical routine.
Inert tracer gas washout tests over single or multiple breaths (SBW or MBW) provide a more sensitive alternative to spirometry in tracking small airway malfunction, e.g. altered ventilation inhomogeneity (VI), and they are more accurate in reflecting structural changes in lung periphery [7]; [7]–[7]].
Nonetheless inert gas washout tests such as SBNT provide information on ventilation inhomogeneity that allows sensitive detection of small airway obstruction even when RV/TLC or other standard spirometry values are normal [ 30- 33].
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