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We postulated that relaxin and β-estradiol might similarly contribute to the enhanced degradation of matrices in fibrocartilaginous tissues from synovial joints, which may help explain the preponderance of diseases of specific fibrocartilaginous joints in women of reproductive age.
It is possible that the preponderance of disease mutations in these portions of the tRNA arises because the mutations further destabilize the already weakly stable native state, shifting the equilibrium to the misfolded intermediate.
As a black woman and a native of a developing nation, this area particularly interests her because of what she sees as a lack of emphasis on infectious diseases and the preponderance of such diseases in Africa.
Rich countries have completed the shift from an epidemiological era characterized by the preponderance of communicable diseases to one characterized by NCDs (Frenk et al. 1994).
The preponderance of this disease is identified through general medical and dental care [ 12- 14].
Although neither study examined T-LBL exclusively, their large sample sizes and the preponderance of T-cell disease within LBL both suggest that results are likely generalizable to T-LBL.
The majority of cases were male (64%) reflecting the sex preponderance of disease.
Here we demonstrate for the first time that the augmentation of mtDNA copy numbers in a MERRF patient is a tissue-specific phenomenon, which might help to explain the preponderance of certain organs for disease-specific symptoms.
In established disease, the preponderance of IFNγ-expressing and paucity of IL-4-expressing T cells, in situ and ex vivo, had until recently led to the description of RA as an immune mediated inflammatory disease associated with a predominantly T helper type-1 (Th1 -like cyTh1 -likeofile [ 1- 3].
The preponderance of these cases are attributable to endemic disease caused by the species S. flexneri (Vinh et al., 2009; Ud-Din et al., 2013; Livio et al., 2014).
Hormone level differences between men and women are accepted as underlaying human sexual dimorphism and are believed to explain the preponderance of one sex over the other for numerous diseases: cardiomyopathy [2], [3], multiple sclerosis [4] and Lupus erythematosus [5].
Being a terminologist, I care about word choice. Ludwig simply helps me pick the best words for any translation. Five stars!
Maria Pia Montoro
Terminologist and Q/A Analyst @ Translation Centre for the Bodies of the European Union