The effects of systemic drug treatments on central nervous system function may vary across mammalian species (i.e. cats vs. humans); therefore complementary studies in humans are required.
The second is for systemic drug delivery.
The patient reported no systemic drug intake except for analgesics for constant lumbar back pain.
Systemic drug administration would be sufficient for targeting in such a case.
For systemic drug delivery, the buccal region offers an attractive route of drug administration.
The hydrophobic polymeric core of the platform readily encapsulated the water-insoluble drug for systemic drug delivery.
The interest for transmucosal dosing for systemic drug delivery is increasing, e.g. buccal, sublingual and nasal routes.
The objective of this study is to investigate the dermatopharmacokinetics and systemic drug disposition after topical application and topical injection.
Solid oral dosage formulations must be designed to produce predictable and consistent systemic drug exposure in the human body.
This study was conducted to assess the systemic drug release and distribution of sirolimus-eluting coronary stents.
Nanofiber scaffolds for local or systemic drug delivery through the oral mucosa, however, have not been fully explored.
