Exact(3)
Four days after the initial examination, repeat MRI showed substantial progression of signal abnormality in cerebral hemispheres, thalamus, and midbrain.
Thirthy three patients of our series have been clinically followed up in a range of 4 12 years and have not shown any substantial progression of the disease.
However, two of them developed an increase of the T2-signal (#5, #12) while in two patients a substantial progression of the necrotic tumor area could be detected (#12, #14) at time.
Similar(5)
In view of substantial progression without other potential treatment options vemurafenib was re-challenged in August 2013, but substantial clinical benefit did not come.
There are, however, no objective criteria regarding the degree of changes that would indicate a substantial initiation or progression of OA.
Irrespective of whether stress hormones promote cancer progression directly by affecting malignant cells, or indirectly by suppressing host immunity or altering other aspects of host physiology, it appears that stress hormones and pro-inflammatory factors play a substantial role in the progression of solid tumors.
Therefore, OPN protein may play a substantial role in tumor progression of vessel sarcomas [ 21].
In general, the aberrant miRNA expression provides substantial consequences for the progression of tumorigenesis [ 40].
Related(20)
substantial completion of
important progression of
substantial development of
substantial upsurge of
substantial rise of
massive progression of
fundamental progression of
great progression of
remarkable progression of
noticeable progression of
substantial spread of
substantial headway of
substantial advancement of
serious progression of
substantial advance of
substantial trend of
substantial stage of
substantial advances of
substantial advancements of
marked progression of
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