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In addition to the deacetylation of histones, SIRT1 also deacetylates non-histone proteins such as various transcription factors that are involved in growth regulation, the response to stress, and apoptosis in the fundamental progression of cancer.
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We believe that the main objective of studies carried out in experimental models of cerebral ischemic injury must be a better understanding of the fundamental mechanisms underlying progression of the ischemic injury.
It is known that cyclin A2 activity is fundamental for progression of the S phase.
Recently, neuroinflammation has been considered fundamental to the progression of PD [ 2].
This may prove useful to help identify facets fundamental to the progression of particular diseases.
Angiogenesis is fundamental to the progression of many solid tumours including prostate cancer.
The chronic inflammatory state is fundamental to the progression of NAFLD [ 40, 41].
How can Le Pen suggest that multiculturalism in Anglophone countries is leading to the progression of fundamental Islam when France with its rigid interpretation of laicité and screaming inequality has a much bloodier history – and present – with regard to minority communities?
Transforming growth factor-β1 (TGF-β1) plays a fundamental role in the progression of renal diseases.
In these patients, achievement of lower BP levels also is fundamental to limit the progression of renal damage, especially in the presence of significant proteinuria.
Although TGF-β plays a fundamental role in the progression of fibrosis, it is also a cytokine with pleiotropic functions involving in many physiological processes, and not suitable as a target for fibrosis therapy.
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