Sentence examples for strong defect of from inspiring English sources

The effect of cof1-22 on the rate of cable turnover, reported recently, appears much more dramatic than that on actin patches [5], and this correlates with the strong defect of the mutant cofilin in severing tropomyosin-decorated actin filaments observed in this study.

A similarly strong defect of ura4 + circularization was observed for xrc4Δ cells, supporting the idea that Xrc4 acts in the same DSB repair process as Lig4 and Xlf1.

Mutations expected to result in loss or strong defect of the function of clathrin or of its endocytic adaptor AP-2 were shown not to abolish synaptic function (Gu et al., 2008, 2013; Sato et al., 2009).

PC12-27 cells exhibited, on the one hand, the mTORcellspexhibiteded-back conthel proness (thandwas inappreciable in the wt clone); on the other hand, a strong defect of the PI3K cascade, including a low activity of mTORC2.

In lcb1-100 cexpressingssing Pil1-GFP, we observed a strong defect of eisosome assembly already at the permissive temperature: cytoplasmic Pil1-GFP fluorescence was markedly increased compared with wild-type control cells.

Taken together, these results indicate that the ablation of all dbx1-expressing cells results in an absence of dorsal neural tube closure at the midbrain level, a severe reduction in the size of the forebrain, as well as strong defects of craniofacial structures.

The stronger defects of the InvA mutant compared with InvBE suggest that R-loops are more prone to form in rrnA than in rrnE.

The partial sorting defects for vacuolar hydrolases are thus not consistent with the stronger defects of ESCRT mutants in maintaining amino acid levels, protein synthesis and cell growth early during nutrient limitation.

Disruption of OsPPR4 expression led to a strong defect in the splicing of atpF, ndhA, rpl2, and rps12-2 introns and influences the splicing of petB and rps16 introns.

All seven mutants have a strong defect in the expression of these bradyzoite markers.

As shown in Figure 1E and Table S1, the number of oocytes with one or two CID foci decreased from 76.3% observed in wild type to 0% in corolla, indicative of a strong defect in centromere clustering.