Sentence examples for substantial defect of from inspiring English sources

However, various features of the disorganized cortex indicated a more substantial defect of cortical layering (Caviness and Rakic 1978; Rakic and Caviness 1995).

Surprisingly, our own more detailed analyses did not reveal any substantial defect of osteoclast-specific gene expression in PLCγ2−/− cultures, and the expression of NFATc1 was not at all affected by the PLCγ2 mutation (Fig. 4b).

J. Robert Oppenheimer, the physicist who oversaw the creation of the atomic bomb, was lauded as a patriot after the United States dropped the bomb on Japan, but nine years later he was disgraced, accused of Communist sympathies and "substantial defects of character".

However, in the case of the DWCNTs fluorinated at 400 °C, the recovery of strong RBMs from the inner tube and weakened RBMs from the outer tube indicated the selective introduction of substantial defects on the outer tube while preserving the original tubular shape.

The results of the research demonstrate the substantial defect tolerance of the bonded composite components.

Proteasomes from this strain grow at the permissive temperature were proteolytically active but migrated faster than 26S holoenzymes suggesting a more substantial defect than merely loss of labile Rpn12.

We next monitored the accumulation of RAD51 foci following irradiation and found a more substantial defect in INO80-depleted cells (Fig 2B).

The small size of dcko limb buds was not due to any substantial defects in expression of Fgf8 in the apical ectodermal ridge or Sonic hedgehog (Shh) in the zone of polarizing activity (Fig. 7IVA H).

Furthermore, no substantial defects or irregularities of the cartilage overlying the bony cylinders were seen on MRI (Fig.  1).

Brd4 suppression resulted in multiple layers of cytokeratin 6 (CK6 -positive CK6 -positivehe inner root sheath, and we noted expanded E-cellsrin expression upon Brd4 knockdown, indicalong of hyperplasia and substhetinnerefects in cellularootchitecture throughout the follicular and epidermal epithelium.

With the exception of Nef M20, all of the mutant proteins with known defects in the down-regulation of MHC-I in human cells had substantial defects in our in vitro binding assays using purified recombinant proteins.