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Provide slow dose escalation to minimise any side effects.
The safety profile of slow dose increment in 80mg intervals has been previously documented.
However, the majority felt that low initial doses of ULT, with slow dose increases, is an integral part of flare prevention, supporting the motto 'start low, go slow'.
However, in refractory CLL, initial results of ABT-199 treatment have shown potential for tumor lysis syndrome, requiring slow dose escalation.
Indeed they tend to appear at the beginning of the treatment and subside after dose reduction without reoccurring with subsequent slow dose increase (Furukawa et al., 2004; Lee et al., 2013).
If these drugs are to be given in such patients, then they should be initiated with (i) strict instructions on how to take the drug, (ii) low initial doses and slow dose titration, (iii) constant clinical supervision, so as to detect constipation at an early stage and (iv) the use of high fiber diet and/or laxatives.
Similar(54)
They reformulated the drug in the form of capsules that fed slow doses to the intestine, but by that time the mice were elderly.
A significantly lower amount of waste was attained with a long spheronization time and slow dosing.
All samples resulted in slow, dose-dependent precipitation of particles after an initial incubation of 3 8 days.
In the presence of 0.1 mM calcium and phosphate, a progressive, slow, dose-dependent turbidity increase was seen with subsequent addition of either BSF or HSA.
Despite its proven effectiveness, there are several recognized disadvantages of warfarin, including a narrow therapeutic range, drug drug interactions that can be delayed, food drug interactions, slow dose-adjustment time, and genetic variability in the enzymes involved in its metabolism, all of which can affect INR [ 16].
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