They allow easy dosing with a high potential for systemic administration that helps prevent hepatic first pass metabolism.
11, 16 Allopurinol is the preferred urate-lowering agent in view of its efficacy in overproducers and underexcretors of serum urate, relatively easy dosing regimen, low cost, and generally acceptable safety profile.
Support ranged from simple encouragement to "keep taking your pills," to presenting pills and accompanying water and/or food for easy dosing at the scheduled time, to running after a departing spouse with a forgotten pill bottle in hand.
64 In fact, the main aspects of a cART regimen in an organ transplant recipient infected with HIV-1 should meet at least the following requirements: be potent with a high resistance barrier; have a low toxicity profile and lack of interactions with immunosuppressive agents; no (or low) impact on graft function; and easy dosing.
The only consistent advantage of such combined therapy is reduced insulin dose requirements, which may result in less daily injections, easier dose titration, and improved compliance (46).
The latter, in this scenorio, offers the favorable advantages over the combined therapy due to the multi-functional convenience, easier dosing regimens, and potential lower costs.
These additional treatment options with risedronate provide easier dosing alternatives for patients.
The lack of need for dose adjustment has the advantages of easier dosing and a reduced risk of overdosing.
Risedronate is an oral, nitrogen-containing bisphosphonate that possesses properties that provide easier dosing alternatives for patients, such as strong affinity for bone, potent antiresorptive action, high concentration and persistence in bone tissue, and excellent tolerability.
