significantly elevated expression

USAGE SUMMARY

The phrase "significantly elevated expression" is correct and usable in written English.
It can be used in scientific or medical contexts to describe a notable increase in the level of expression of a gene, protein, or other biological marker. Example: "The study revealed a significantly elevated expression of the target gene in cancerous tissues compared to normal tissues."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

In line with the results obtained here, CRCs belonging to the CMS2 subtype, which is characterized by high WNT and c-MYC activity, showed significantly elevated expression of AP4 when compared with the three other CMS subtypes (Supplementary Fig. 10a).

Nature

In the CA3, CRS and CRS+Spironolactone significantly elevated expression compared to control.

Plosone

RT-PCR and Western blotting revealed significantly elevated expression of Shh gene (12-fold) and protein (4.5-fold) in ShhMSCs as compared with EmpMSCs (Figure 1A & 1B).

Plosone

During differentiation, significantly elevated expression was observed on Day 5 in the Prnp-KO background population; this transcription gradually fell from Day 7 to 13.

Plosone

In A. millepora, both cry1 and cry2 (similar to F. fragum cry1 and cry2) had significantly elevated expression in response to light [19].

Plosone

As revealed by RT-PCR and ELISA, transfection of miR-20b into hMSCs significantly elevated expression levels of BMP-2 and Runx2 both at the mRNA and the protein levels (Fig. 2).

Plosone

Whilst the expression of all these chemokines was elevated during estrus compared to di-estrus (Fig. 2a d), with similar linear trends (Fig. 3a), only CCL4 retained a statistically significantly elevated expression (p<0.0001; t-test) during pregnancy (Fig. 2b).

Plosone

In comparison to cells at either D0 or D5, D33 differentiated cells showed significantly elevated expression of CRX, recoverin and rhodopsin (Fig. 2D), further supporting the fact that retinal photoreceptors were being formed following a 33 day differentiation paradigm.

Plosone

Plasma-membrane transporters are known to show significantly elevated expression noise (Zhang et al. 2009).

Genome Biology and Evolution

As shown in Figure 2A, overall ER- tumors had slightly but significantly elevated expression of JMJD6 (P < 0.001).

Breast Cancer Research

Two genes, Dll and dpp, whose depletion produced phenotypes in the tarsus, showed significantly elevated expression in that tissue.

G3: Genes, Genomes, Genetics

Expert writing Tips

Best practice

When using "significantly elevated expression", ensure that the increase is statistically significant and supported by data. Clearly state the context in which the expression is elevated (e.g., specific tissues, conditions, or treatments).

Common error

Avoid using "significantly elevated expression" solely based on visual observation without statistical validation. Always confirm with appropriate statistical tests to ensure the elevation is indeed significant and not due to random variation.

Linguistic Context

The phrase "significantly elevated expression" functions as a descriptor, modifying a noun. According to Ludwig, it commonly appears to describe quantifiable increases in biological contexts, as showcased across numerous scientific publications.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Encyclopedias

0%

Ludwig's WRAP-UP

In summary, "significantly elevated expression" is a grammatically sound and frequently used phrase, particularly within the scientific domain, to denote a statistically significant increase in gene or protein expression. Ludwig AI confirms its correct usage in various contexts. To ensure accuracy, always validate claims of significantly elevated expression with statistical backing and specify the context. Alternatives like "markedly increased expression" or "substantially heightened expression" can be employed for variety. However, "significantly elevated expression" implies a level of statistical validation that the alternatives do not necessarily convey.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

markedly increased expression

Replaces "significantly" with "markedly", emphasizing a noticeable increase.

substantially heightened expression

Uses "substantially heightened" to suggest a considerable rise in expression.

notably upregulated expression

Replaces "elevated" with "upregulated", a term frequently used in biology to indicate increased gene expression, and "significantly" with "notably".

considerably increased expression

Substitutes "significantly" with "considerably", indicating a large increase.

appreciably raised expression

Employs "appreciably raised" to denote a noticeable increase in expression.

prominently enhanced expression

Uses "prominently enhanced" to highlight a clear and distinct increase in expression.

distinctly augmented expression

Replaces "elevated" with "augmented", suggesting an increase, and "significantly" with "distinctly".

remarkably increased expression

Substitutes "significantly" with "remarkably", emphasizing an extraordinary increase.

statistically significant increase in expression

Replaces "significantly elevated" with a more explicit statistical description.

demonstrably higher expression

Replaces "significantly elevated" with "demonstrably higher", focusing on the evident increase in expression.

FAQs

How do I use "significantly elevated expression" in a sentence?

Use "significantly elevated expression" to describe a notable increase in the level of a gene, protein, or other biological marker that has been confirmed through statistical analysis. For example: "The study revealed a "significantly elevated expression" of the target gene in cancerous tissues compared to normal tissues."

What can I say instead of "significantly elevated expression"?

You can use alternatives like "markedly increased expression", "substantially heightened expression", or "notably upregulated expression" depending on the context.

Which is correct, "significantly elevated expression" or "significant elevation in expression"?

Both phrases are grammatically correct, but ""significantly elevated expression"" emphasizes the nature of the expression itself, while "significant elevation in expression" emphasizes the change or increase. The choice depends on the specific focus of your sentence.

What's the difference between ""significantly elevated expression"" and "increased expression"?

"Significantly elevated expression" implies that the increase is not only present but also statistically significant, meaning it's unlikely to have occurred by chance. "Increased expression" simply indicates a rise in expression levels without necessarily implying statistical significance.