markedly increased expression

USAGE SUMMARY

The phrase "markedly increased expression" is correct and usable in written English.
It can be used in contexts such as scientific writing, particularly in biology or genetics, to describe a significant rise in the expression of a gene or protein. Example: "The treatment resulted in markedly increased expression of the target gene, indicating a strong response to the therapy."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

42 human-written examples

Under physiological conditions, the IGF2 maternal allele is silenced by genomic imprinting, and the gene is expressed only by the paternal allele; however, WT exhibits a markedly increased expression relative to DK.

Cell Death and Disease

Immunohistochemical studies have shown that ALOX5, ALOX5AP, and LTA4H are abundantly expressed in arterial walls of CAD patients, with ALOX5 having markedly increased expression in advanced lesions and localizing to macrophages, dendritic cells, and neutrophilic granulocytes (Qiu et al. 2006; Spanbroek et al. 2003).

Human Genetics

Interestingly, diaphragms from mdx mice display markedly increased expression of CCR2 and its chemokine ligands and increased recruitment of Ly6Chi monocytes that differentiate into CD11bhi macrophages [273].

Clinical and Translational Medicine

These genes were selected for validation because of their markedly increased expression levels and they were classified on the basis of gene ontology.

Reproductive Toxicology

By cultivation, p75NTR+ cells showed features of adult HSCs with markedly increased expression of glial fibrillary acidic protein and α-smooth muscle actin.

Gastroenterology

These genes, i.e., characteristically associated with osteocyte, osteoblasts and osteoclasts, showing markedly increased expression, encode secretory proteins.

Plosone

Human-verified similar examples from authoritative sources

Similar Expressions

18 human-written examples

1,25(OH)2D3 markedly increased expressions of TJ proteins and mRNA and decreased the FITC-D permeability and the level of LPS.

BMC Gastroenterology

R6/2 HD mice with oral B401 treatment significantly reduced reactive oxygen species levels in the blood, but markedly increased expressions of superoxide dismutase 2 in the brain tissue.

Clinical interventions in aging

For example, if one of the cis-regulators markedly increases expression while the other decreases expression, and one protein is defective while the other is normal, then one combination of cis-regulators with the protein-coding alleles will produce wellness whereas the other combination will produce disease [ 4].

Genome Medicine

Peripheral nerve injury may lead to neuropathic pain and cause a markedly increase expression of growth associated protein-43 (GAP-43) in the spinal cord and dorsal root ganglion, local anesthetics blocking electrical impulse propagation of nerve fibers may also affect the expression of GAP-43 in the spinal cord and dorsal root ganglion.

Neural Regeneration Research

CXCL10 slightly increased RANKL expression in RA synoviocytes, but markedly increased RANKL expression in Jurkat/Hut 78 T cell or CD4+ T cell.

Arthritis Research and Therapy

Expert writing Tips

Best practice

When describing experimental results, quantify the increase in expression whenever possible (e.g., "Markedly increased expression, with a 3-fold increase compared to control.") to provide more specific information.

Common error

Avoid using "markedly increased expression" in general writing. This phrase is most appropriate for scientific or technical contexts. In other situations, use simpler alternatives like "significantly higher" or "much greater".

Linguistic Context

The phrase "markedly increased expression" functions as a descriptive term, specifically as a noun phrase modified by an adverb and an adjective. It's used to describe the state of a gene or protein level after a specific event or condition. Ludwig AI confirms its typical use in scientific literature.

Expression frequency: Common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

The phrase "markedly increased expression" is a grammatically correct and widely used term in scientific writing to denote a significant elevation in the amount of a gene or protein. According to Ludwig, it is most appropriately used in scientific or technical contexts. While alternatives like "significantly elevated expression" and "substantially heightened expression" exist, this phrase effectively conveys a clear and notable increase. When employing this phrase, especially in reporting experimental results, consider quantifying the increase for more clarity. Although commonly encountered in scientific publications, its usage in non-technical contexts should be avoided.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

significantly elevated expression

Replaces "markedly" with "significantly" and "increased" with "elevated", both conveying a strong increase.

substantially heightened expression

Uses "substantially" instead of "markedly" and "heightened" instead of "increased", emphasizing the magnitude of the increase.

notably augmented expression

Substitutes "markedly" with "notably" and "increased" with "augmented", suggesting a considerable amplification.

distinctly raised expression

Employs "distinctly" for "markedly" and "raised" for "increased", indicating a clear and noticeable elevation.

sharply upregulated expression

Replaces "increased" with "upregulated", common in biological contexts, and "markedly" with "sharply".

considerably amplified expression

Uses "considerably" instead of "markedly" and "amplified" instead of "increased", highlighting a significant expansion.

remarkably enhanced expression

Substitutes "markedly" with "remarkably" and "increased" with "enhanced", indicating an exceptional improvement.

greatly boosted expression

Replaces "markedly" with "greatly" and "increased" with "boosted", suggesting a substantial and positive surge.

strikingly intensified expression

Employs "strikingly" for "markedly" and "intensified" for "increased", conveying a vivid and pronounced effect.

pronounced elevation in expression

Replaces "markedly increased" with "pronounced elevation", changing the structure while retaining the meaning.

FAQs

How can I use "markedly increased expression" in a sentence?

You can use "markedly increased expression" to describe a significant rise in the level of a gene or protein. For example: "The treatment resulted in a "markedly increased expression" of the target gene."

What are some alternatives to "markedly increased expression"?

Some alternatives include "significantly elevated expression", "substantially heightened expression", or "notably augmented expression". The best choice depends on the specific context.

Is "markedly increased expression" formal or informal?

"Markedly increased expression" is considered formal and is typically used in scientific or technical writing. For more casual contexts, you might prefer simpler phrases.

What does "markedly increased expression" imply about the change?

It implies that the change in expression is substantial and easily noticeable. The term "markedly" emphasizes the significance of the increase.