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Many paintings by Van Gogh and his contemporaries have severely changed color since they were made [1 7].
It is not always clear to us what Rembrandt's intentions were, since many of his late pictures have severely changed in appearance over time, as a result of paint alterations and old restorations.
But now that he needs to pander to the Tea Party, he's severely changed his tune.
Unfortunately, the above is likely to sound like deja-vu to anyone who followed the SEC's haphazard implementation of the ill-fated short sell bans last fall The regulatory agency severely changed the overall structure of the market literally overnight, thus causing anything but "fair, orderly and efficient markets".
It is also noticed that the conformation of switch 1 element is severely changed in the GTP-bound system comparing with the GDP and GDP+Pi bound systems (see Figure 6B).
Though severely changed, structural and functional "signatures" of these ancestors could survive in contemporary functional motifs.
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Compared to interaction in solution, anchoring of proteins into the membrane severely changes the energetic landscapes of protein protein interaction.
However, for shallow indents (nanoindetation data), the slope of the line severely changes, decreasing by a factor of ten, resulting in a "bilinear behavior".
When a high speed train enters into a tunnel, the aerodynamic forces severely change and, consequently, the stability and performance significantly deviate from the value of design point which is usually set at cruising speed on the plain ground.
The results obtained from the performance degradation analysis of the fractal model appears more severe than the result of the periodic models, due to the fact that the fractal model contains more roughness information, which severely changes the transmission path of the electromagnetic wave.
As for the CV curves in KOH electrolyte, although there is no obvious redox peaks, RGOA also exhibits pseudocapacitance besides electric double-layer capacitance at the potential window of −1.0 ~ −0.3 V because the current density severely changes as the potential varies within this potential window [21].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com