The splicing of several MBNL1 and CUG-BP1 pre-mRNA targets is subsequently severely altered in DM1-affected tissues.
The current stadium, which was severely altered in the mid-1970's, has little architectural merit.
Ultimately, land reclamation and dam construction have severely altered the fate and transport of sediment within the estuarine system.
Rapid human-induced conversion and degradation of natural habitats has severely altered patterns of species occupancy and population viability.
A severely altered level of consciousness (ALC) has been considered a contraindication to noninvasive positive pressure ventilation (NPPV).
Climate has been severely altered as continents have changed position, not only in latitude but also with respect to one another.
Newer parks are more beneficial to hitters, he said, and the construction of a new seating tier behind home plate has severely altered wind patterns.
My daughter Flora, who died in the Lockerbie bombing in 1988, was mostly intact, though her face was severely altered by decompression.
That is, consciousness remains severely altered but, in contrast to the vegetative state, there is minimal but definite behavioural evidence of self or environmental awareness.
The balance between load and discharge that ultimately determines whether a river will deposit or erode is severely altered during glacial episodes.
Thus, the ALDH2*2 enzymatic activity is severely altered even in heterozygous individuals carrying rs671 and is reportedly associated with conditions such as alcohol flush syndrome20, 21.
