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The shapes of the nuclei are irregular and the ratio of nucleus to cytosol area is grossly changed.
The protein levels of MTH1 or OGG1 did neither appear to be grossly changed by MSH2 deficiency nor methotrexate exposure.
Samples for histopathology were collected from lung, trachea, stomach, intestine, oesophagus, liver, adrenal gland, kidney, testis, ovary, spleen, thymus, lymph nodes, heart, aorta, skeletal muscle, skin, feathers, brain, spinal cord and from grossly changed organs and tissues.
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Answers to these queries would likely solidify but probably not grossly change the current set of morphological observations.
The reduction of the disulphides does not grossly change the secondary structure but does alter the environment around specific aromatic residues thereby altering their fluorescence.
Grayling today told the Guardian he was not wedded to the law's language being changed to "grossly disproportionate" and suggested there could be alternative ways to amend the legislation.
Presumably this re-tuning would also have to be relatively rapid, because the color-appearance of objects does not change grossly when the illuminant is changed (e.g., [ 82]); this is sometimes referred to as "discounting the illuminant".
Grossly, degenerative changes were noted in articular cartilage of DES-exposed animals at a higher rate than those in controls.
Interestingly, WT and CD36−/− mice had equivalent levels of free fatty acids and LDL, suggesting that metabolic improvements in CD36−/− mice were not due to grossly detectable changes in circulating ligands (Supplementary material online, Table S1 ).
The Tories said that the wording was too open-ended and should be changed to allow anything other than "grossly disproportionate" force.
This is reflective of our grossly outdated copyright law, and a lot has changed since fair use was first defined in 1976.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com