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Compound 5 showed selective activities against tumor cells without toxicity to the non-tumorigenic human breast MCF10A epithelial cell line.
Compound 1 displayed cytotoxicity towards all the nine tested cancer cell lines with IC50 values below or around 65 μM while other metabolites showed selective activities.
Compound 8, a water soluble succinic acid salt of N,N-dimethyl-N-deacetylthiocolchicine (5), showed selective activities against HCT-8 and SK-BR-3 cells.
The data related in this paper are related to "Environmental-behavior studies of sustainable construction of the third place – based on outdoor environment-behavior cross-feed symbiotic analysis and verification of selective activities" (Ren, 2017) [1].
Retinoid-related molecules with an adamantyl group (adamantyl arotinoids) have been described with selective activities towards the retinoid receptors as agonists for NR1B2 and NR1B3 (RARβ,γ) (CD437, MX3350-1) oRARantagonistssts (MX781) that induce growth arrest and apoptosis in cancer cells.
This difference clearly indicates the selective activities of the acyl-CoA reductase and the alkyl DHAP synthase which are involved in the synthesis of the obligatory precursor of ether lipids, alkyl DHAP (Figure 8).
Similar(36)
Novel PPAR-γ agonists with selective activity and potentially improved safety are under active investigation [55].
Compounds 4 and 6 displayed selective activity on leukemia and carcinoma cells, whilst 1 3 were not active.
Additionally, this molecule demonstrated selective activity for L. donovani, when compared with the activity against T. b. brucei.
Compound 4m with 4-methoxybenzene moiety exhibited the best potential selective activity against PDE4B.
2-Methyladenosine (methyl-Ado) has selective activity against Mycobacterium tuberculosis (M. tuberculosis).
Related(20)
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