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Novel PPAR-γ agonists with selective activity and potentially improved safety are under active investigation [55].
Compounds 4 and 6 displayed selective activity on leukemia and carcinoma cells, whilst 1 3 were not active.
Compound 4m with 4-methoxybenzene moiety exhibited the best potential selective activity against PDE4B.
2-Methyladenosine (methyl-Ado) has selective activity against Mycobacterium tuberculosis (M. tuberculosis).
Some quinolines showed moderate, although selective activity against CVB-5, Reo-1 and RSV.
Two water-soluble compounds, C2 and C4 exhibit selective activity in EVSA-T cell line.
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A data sets with three or more targets contains also more non-selective activity profiles.
We have discovered and demonstrated the in vitro and in vivo PPARδ-selective activity of novel Y-shaped agonists.
Traditional cancer chemotherapeutic agents typically exhibit non-selective activity and often produce low response rates and severe toxic side effects in patients [1].
However, it remains unclear how HDACi exert this cancer cell-selective activity.
Such category-selective activity patterns imply a number of candidate factors affecting object representations in visual cortex.
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