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The primary end point of the ≥50% response threshold was evaluated by validity and responsiveness analysis.

The responsiveness analysis, including effect size (ES) and standardized response mean (SRM), is presented in Table 2.

Design: Prospective longitudinal design with correlation and responsiveness analysis.

[24] Patients reporting meaningful change (much worse, worse, improved, much improved) were included in the responsiveness analysis to detect the ability of the PROs to measure meaningful levels of change.

Feasible and functional CRPC models for drug responsiveness analysis and the development of effective therapies targeting the FGF signaling pathway and other pathways in prostate cancer are being actively investigated.

For this responsiveness analysis, missing data was not imputed.

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Similar(17)

Therefore, in addition to identifying the Amazon as a region of particularly strong physical climate responsiveness, our analysis reveals the potential for particularly acute impacts arising from existing ecosystem vulnerability to the combined effects of severe heat and severe drought.

The psychometric properties of the scale were evaluated with respect to validity, reliability and responsiveness employing correlation analysis, factor analyses, multi-trait scaling analysis, t-tests and also G studies and D studies of Genralizability Theory analysis.

This, in combination with the results from responsiveness to change analysis, suggests that the PGI cannot be relied upon as an index of change in quality of life in this patient population.

We also computed the degree of change in symptoms independent of initial severity as residual change in symptoms by regressing the initial PANSS (total and subscales) scores on follow-up scores as a further outcome measure of CBT responsiveness for fMRI analysis following the method used by Siegle and colleagues (22).

The analysis of responsiveness revealed significant dose-response trends (Jonckheere-Terpstra test, ps < 0.001).

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