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Exact(12)
Further, we estimated the relative duplication time of the two gene families.
As an illustration, we use the SOPH framework to predict the relative duplication order between pairs of ancestral bZIP proteins.
Additional studies are required to estimate relative duplication rates of foreign and indigenous genes, rates of mutations, and paralog silencing in this group of organisms.
This relatively good performance means that there is a substantial amount of information about the relative duplication order of proteins encoded in the network.
Thus, to predict the relative duplication order of u and v, we can simply compare the probabilities P u and P v and predict that the protein having the larger of the two probabilities was the first to duplicate.
The ensemble of histories that is compactly encoded by the hypergraph can also be used to answer other queries about the histories themselves, such as inferring the relative duplication order of proteins within a species.
Similar(48)
Based on phylogenetic trees constructed from TR sequences, orthologous subfamilies were identified from gene families along with the relative gene duplication events.
The algorithm is applied to reconstructing ancestral interactions among bZIP transcription factors, imputing missing present-day interactions among the bZIPs and among proteins from five herpes viruses, and determining relative protein duplication order in the bZIP family.
We now describe the performance of the SOPH framework for the three inference tasks—ancestral network reconstruction, missing interaction imputation and determination of relative protein duplication order set forth in Section 1.
For example, single small-scale duplications typically result in greater expression-level diversification relative to duplications via WGD in Arabidopsis (Casneuf et al. 2006).
The increased number of duplications is even more pronounced when considering the relative number of duplication events per branch instead of the absolute abundance and hence points to a major duplication event in the evolution of the Phytophthora genus (fig. 3 and supplementary additional file 6, Supplementary Material online).
Related(20)
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