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Musculoskeletal side effects also necessitated reduced dosing in some patients.
The intervention by Roberts et al 8 (GFR+) also reduced dosing errors with gentamicin and vancomycin.
Pulsatile drug delivery offers the following advantages: (i) extended daytime or nighttime activity, (ii) reduced side effects, (iii) reduced dosing frequency, (iv) reduction in dose size, (v) improved patient compliance, and (vi) lower medication costs due to the reduced dosing.
Reduced dosing for pregabalin may allow better tolerability, although this generally does not apply for duloxetine or milnacipran.
Most conventional drugs are small water soluble molecules and many treatment regimes would benefit from the enhanced bioavailability and reduced dosing frequency that transdermal delivery offers.
Local chemotherapy, provided by either biodegradable polymer implants or convection-enhanced delivery, has been utilized to bypass the BBB and provide sustained drug release, leading to improved toxicity profiles and reduced dosing frequency.
Similar(37)
These systems are meant to improve drug storage security, reduce dosing errors, and improve charge capture, among other features.
Reduced dose and dosing frequency could also minimize any dose-related toxic side effects.
Reduced doses and more frequent dosing could dilute out the adverse effects and still produce some beneficial effects.
But it wasn't until earlier this month that the F.D.A. reduced doses of Ambien for women by half.
The rationale and outcome data for hypofractionated and/or reduced dose regimens are discussed.
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