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(Because of this, BMD analysis is considered inappropriate for certain data sets, such as those with small dosing groups).
The relationship between dose and systemic exposure was inconclusive due to the small PK data set within each arm, large interpatient variability and the small dosing range from 6.5 to 10.0 mg m 2.
A consequence of this from a treatment perspective is that if a sclerostin mAb is dosed with a small dosing interval, and the mesenchymal-derived pre-OB do not have sufficient time to be replenished, the anabolic effect of the mAb will be diminished with repeated doses.
In this context, the assessment of the relationship between dose and systemic exposure was inconclusive, not only due to a lack of PK data within each arm, but also because of large interpatient variability and a small dosing range from 6.5 to 10.0 mg m 2.
Similar(47)
In small doses, naturellement.
Even relatively small doses work.
In small doses, that is.
Take it in small doses.
Well, only in small doses.
"In small doses, it's sweet".
But those small doses are stylistically distinct.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com