'profound improvement' is correct and usable in written English. You can use it to describe a large, sudden, or drastic change or improvement, typically for the better. For example, "The implementation of the new policy led to a profound improvement in the company's employee satisfaction ratings."
Nowadays, the notion that life is measurably improving – and there can be no more profound improvement than not being killed or tortured – is about as unfashionable in educated circles as the conviction that western culture is in any sense civilising.
We encourage you to nominate individuals or groups that have made a profound improvement in daily work life.
These EE-dependent changes likely underlie the profound improvement in survival of colon-tumor-bearing Tcf4Het/+ ApcMin/+ males.
It requires nothing less than an infusion of additional aid sufficient to achieve a profound improvement in the quality of education offered by the city's public schools.
In 2013, an NIH study demonstrated that chelation effectively removes many heavy metals from the human body; patients with a high risk of mortality before the trial showed profound improvement after chelation.
It has been shown in 2 independent clinical studies with a case-control design that treatment of kidney donors with catecholamines protects against rejection after kidney transplantation and is associated with a profound improvement of long-term graft survival.
The Good Friday agreement promised profound improvements in human rights for people in Northern Ireland.
These tools also have the potential to bring profound improvements to business.
My job has been to disagree robustly, because the north needs the new blood and the talking-up that have led to profound improvements since 1987.
The end of apartheid, a system that Mr. Mandela played a central role in dismantling, has brought profound improvements in Qunu, as it has across South Africa.
Of course, Chamberlain started out as a Liberal, but he was only able to make the profound improvements that he did because of the social reform legislation introduced by Disraeli.
I love the desktop app, it’s always running on my Mac. Ludwig is the best English buddy, it answers my 100 queries per day and stays cool.
Cristina Valenza
Retail Lead Linguist @ Apple Inc.