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However, in yeast and mammals there is cross-talk between cholesterol biosynthesis and pathways of adaptation to hypoxia [23], [24].
This work nominates multiple potential pathways of adaptation to naturally stressful environments in a model legume.
We have characterized four pathways of adaptation, each initiated by a single mutant present in the preselection culture prior to plating on selective medium.
These variants illustrate both the common pathways of adaptation to high altitude in different populations and features specific to the Daghestani populations, showing how even a mildly hypoxic environment can lead to genetic adaptation.
A high number of the genomic regions identified with the VarLD method were shown to be associated with physiological pathways of adaptation and production processes, and some of the genes present in these regions have also been reported to coincide with signatures of selection in other species.
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Intriguingly, arenaviruses may have merged as human pathogens by more than one independent pathway of adaptation: clade C New World arenaviruses share with Old World arenaviruses an affinity for α-dystroglycan, a highly conserved cell surface protein involved in adhesion to the extracellular matrix.
This lack of understanding stems partly from difficulties in dissecting the pathways of hypoxic adaptation in pathophysiological states.
Furthermore, we identified distinctive vernalization-dependent and photoperiod-dependent flowering pathways coexisting in allopolyploid B. juncea, suggesting contribution of these pathways to adaptation for survival during polyploidization.
Based on the studies from the past two decades, an emerging model of mROS and signaling suggests that low levels (picomolar to nanomolar range) of mROS are necessary to maintain homeostatic biological processes, while slightly elevated levels of mROS initiate pathways for adaptation to stress.
Pathways to adaptation are indeed part of sustainable development pathways [ 27], and a better understanding of the determinants of adaptive capacity will assist the building of these pathways.
Ketogenesis is an ancient pathway of metabolic adaptation exploited when an organism experiences protracted energy stress [ 26].
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