Sentence examples for pathway block from inspiring English sources

Specific inhibitors of the shikimic acid pathway block accumulation of MAAs, suggesting that MAA biosynthesis in the eukaryotic partnership of corals proceeds from a shikimate branch point thought to be at 3-dehydroquinate [21], [22], [23], [24].

It has been shown that TZDs inhibit key steps in the ERK/MAPK pathway, block the events that are critical for the re-entry of quiescent VSMCs into cell cycle, thus retard serum-induced growth of cultured arterial VSMCs and PDGF-BB-directed migration of VSMCs [13] [15].

To ensure that the MVA pathway block was due to lovastatin we evaluated the prenylation status of Rap1, a protein that is known to be exclusively geranylgeranylated.

Vascular endothelial growth factor activation of the p44/p42 mitogen-activated protein kinase pathway, which is required for angiogenesis, was supported by adhesion through either α1β1, α2β1, αvβ3, or αvβ5, and pharmacologic inhibition of this pathway blocked proliferation and suppressed survival.

To test this hypothesis in vivo, we analyzed whether SHH pathway blocking enhanced chemotherapy efficacy, cyclopamine or control tomatidine was used to inhibit SHH pathway responses.

Next, we observed the effect of SHH pathway blocking on chemoresistance of tumorsphere cells in vitro and tumor response to drugs in vivo.

We found that transient activation of Wnt/β-catenin pathway during gastrulation has no effect on cardiogenesis, whereas more sustained or later activation of the pathway blocks differentiation of cardiomyocytes without affecting their specification.

Smad4 of the TGF- β pathway blocks TIAF1 aggregation.