Sentence examples for pathway blocked from inspiring English sources

Vascular endothelial growth factor activation of the p44/p42 mitogen-activated protein kinase pathway, which is required for angiogenesis, was supported by adhesion through either α1β1, α2β1, αvβ3, or αvβ5, and pharmacologic inhibition of this pathway blocked proliferation and suppressed survival.

Further analysis revealed that SHH pathway blocked by cyclopamine or 5E1 caused a higher reduction in self-renewing capacity of HGC-27 tumorsphere cells than that of adherent cells.

We also investigated whether SHH pathway blocked by 5E1 or control PBS enhanced chemotherapy efficacy in vivo, the results showed that 10 µg/ml 5E1 treatment led to a significantly greater tumor growth inhibition than those only treated with Oxaliplatin (Fig. 6A,B).

One essential differentiation pathway blocked by the leukemic fusion proteins is calcitriol signaling.

Inhibition of the JNK pathway blocked ceramide-induced autophagy and up-regulation of LC3 expression [ 62].

This suggested that piperine inhibition of the ERK1/2 signaling pathway blocked the migration of AP-1 into the nucleus.

To test this hypothesis in vivo, we analyzed whether SHH pathway blocking enhanced chemotherapy efficacy, cyclopamine or control tomatidine was used to inhibit SHH pathway responses.

Next, we observed the effect of SHH pathway blocking on chemoresistance of tumorsphere cells in vitro and tumor response to drugs in vivo.

Inhibition of HIF-1 α neosynthesis through upper pathway blocking by a PI-3K-Akt inhibitor or HIF-1 α siRNA abolished isoflurane-induced effects.

Glyphosate inhibits a key enzyme, EPSPS, in the shikimate pathway blocking the biosynthesis of several important amino acids and ultimately leads to plant death [ 16, 17].

In this approach we focus on transcriptional effects that can be linked to the phenotypic changes as a result of pathway blocking by ERK knockdown.