Sentence examples for pathway blocking from inspiring English sources
To this end, multiple autoimmune models have been tested in mice that are genetically deficient in LTαβ/LTßR molecules or tested in mice that are treated with LTαβ/LIGHT pathway blocking agents.
To test this hypothesis in vivo, we analyzed whether SHH pathway blocking enhanced chemotherapy efficacy, cyclopamine or control tomatidine was used to inhibit SHH pathway responses.
Next, we observed the effect of SHH pathway blocking on chemoresistance of tumorsphere cells in vitro and tumor response to drugs in vivo.
Annexin, a phospholipid-binding protein that binds to membrane phospholipid phosphatidylserine, is released into the external cellular environment in apoptotic cells, whereas Bcl-2 expression is regulated by cytokine signaling through the JAK-STAT pathway, blocking apoptotic signals [32], [33].
We also found that SHH pathway blocking strongly enhanced the efficacy of chemotherapeutic drugs in HGC-27 tumorsphere cells in vitro and in vivo but had no significant effect in adherent cells.
Results showed that tumorsphere cells from gastric cancer specimen also had chemoresistance and tumorigenic capacity, moreover SHH pathway blocking reduced the chemoresistance of tumorsphere cells and enhanced tumor response to drugs in vivo.
Vascular endothelial growth factor activation of the p44/p42 mitogen-activated protein kinase pathway, which is required for angiogenesis, was supported by adhesion through either α1β1, α2β1, αvβ3, or αvβ5, and pharmacologic inhibition of this pathway blocked proliferation and suppressed survival.
One essential differentiation pathway blocked by the leukemic fusion proteins is calcitriol signaling.
Inhibition of the JNK pathway blocked ceramide-induced autophagy and up-regulation of LC3 expression [ 62].
This suggested that piperine inhibition of the ERK1/2 signaling pathway blocked the migration of AP-1 into the nucleus.
The inhibition of ERK or JNK pathways, but not the p38 pathway, blocked GM-CSF or M-CSF-induced monocyte-macrophage differentiation (Supplementary information, Figure S4A).
