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Exact(18)
We systematically assessed how each of the seven possible combinations of His>Ala substitutions modifies the elaboration of three key disease-linked phenotypes, namely: (1) survival in an oxidising environment; (2) survival in a non-oxidising environment; and (3) the proportion of Aβ toxicity that is metal dependent.
For example, the median survival under non-oxidising conditions did not correlate with the survival of flies in an oxidising environment (Fig. 7D, R=0.0003), whether or not we grouped the data according to the presence of the H6A substitution.
Proposed repository concepts also include engineered barriers such as copper canisters, the corrosion of which increases considerably in an oxidising environment compared to prevailing reducing conditions.
Defence genes, such as epoxide hydrolase and glutamate cysteine ligase then become up-regulated in an attempt to reduce the oxidising environment.
In this study the influence of CeO2 addition to a Pt/Al2O3 catalyst for low temperature (<540 °C) methane oxidation in an oxidising environment has been investigated.
An oxidising environment at the depth of the repository would increase the solubility and mobility of many radionuclides, and increase the potential risk for radioactive contamination at the ground surface.
Similar(42)
The contribution of each histidine to toxicity is different in oxidising versus non-oxidising environments.
Aβ and iron exhibit distinct toxicity mechanisms in oxidising and non-oxidising environments.
In a non-oxidising environment the survival of flies expressing the various peptides is determined by position-dependent factors.
By contrast, the number of histidines did not correlate with the median survival of flies in a non-oxidising environment (Fig. 7C).
The implication of these results is that much of the metal-mediated toxicity, in a non-oxidising environment, is dependent on H6A and that, thereafter, there are smaller position-dependent effects of residues 13 and 14.
Related(17)
combustion environment
oxidant environment
oxidizer environment
oxidising environments
oxidative environment
dye environment
oxidising atmosphere
oxidising agent
oxidising system
oxidising aluminum
oxidising equivalent
oxidising hydrogen
oxidising enzyme
oxidising power
oxidising alkaline
oxidising air
oxidising metal
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