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Exact(5)
The absolute magnitudes of both gains and losses altered the strength of conflict.
Careful individual analysis of each gene family is sure to increase the number of both gains and losses on every branch of the tree.
Chromosome 10 harbors the oncogene FGFR2 (10q26) and tumour suppressor genes PTEN/MMAC1 (10q23) and DMBT1 (10q25-q26), both involved in carcinogenesis, which could explain the observation of both gains and losses of chromosomes 10 in gastric carcinomas [ 34- 36].
The number of foreign genes in any bdelloid genome is the result of both gains and losses over time, so the higher number of foreign genes in some species could conceivably be due to either or both of these processes: more gains in some species or more losses in others.
Tumors typically showed whole chr.9 loss, likely targeting multiple tumor suppressors (i.e. INK4A, PTCH1, and TSC1) whereas the cell lines had a high frequency of both gains and losses of chromosome 9, often in association with UPD affecting either the whole chromosome or its q-arm.
Similar(55)
The exception was in nucleus breeding schemes that had very short generation intervals, resulting in higher rates of both gain and inbreeding.
Entrained with the central respiratory network is the sympathetic nervous system, which exhibits patterns of discharge coupled with the respiratory cycle (in terms of both gain and phase of coupling) and dysfunctions in this coupling appear to underpin pathological conditions.
Therefore it is prudent to use a wide range of both gain and loss of function experiments in order to fully understand the function of PPARδ and its relationship to PPARα and PPARγ signalling.
This novel mutation exhibits a phenotype with characteristics of both gain-of-function and loss-of-function mutations.
Hence, one hypothesis is that the Alexander phenotype reflects a combination of both gain of function (GFAP) and loss of function (αB-crystallin).
It is also possible that these disease are caused by the combinatorial effects of both gain and loss of function of FUS/TLS.
Related(20)
of both animals
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of both trains
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