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The direct effect of temperature per se on myocardial function has been the subject of various previous studies.
However, what clinical features of DM patients are associated with impaired LV longitudinal systolic myocardial function has not been fully investigated.
Therapeutic angiogenesis, which can improve blood flow, revascularization, and myocardial function, has proved to be one of the most promising therapies for cardiovascular disease.
The evidence of a clinical impact of diabetic cardiomyopathy on myocardial function has increased in recent years, mainly because of refined echocardiographic methods such as tissue Doppler techniques.
EF is likely to recover and there is evidence that it is relatively safe to readminister trastuzumab after it has been discontinued and myocardial function has returned to baseline [ 13].
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Modest improvements in myocardial function have been suggested to merely arise from paracrine effects [ 5– 7].
Abnormalities in myocardial function have also been described in healthy adolescents with type 1 diabetes at rest (10– 12) but not during exercise.
Similar changes in myocardial function have been observed in DOCA-salt rats administered with resveratrol (1 mg/kg) for a period of four weeks and have been attributed to the attenuation of anti-inflammatory, oxidative stress, and antifibrotic pathways [ 5].
Advances in understanding the role of NO signaling in myocardial function have encouraged recent research into whether NOS uncoupling contributes to the pathogenesis of several aspects of heart failure.
Although studies incorporating direct visualization of myocardial function have yet to be performed in RA patients, clues from animal models of CHF induced by chronic cytokine excess (a setting that may mimic the RA disease state) may serve to explain the apparent contradictions in treatment effects of cytokine inhibition on the myocardium.
Assessment of myocardial longitudinal function has proved to be a sensitive marker of deteriorating myocardial function in aortic stenosis, demonstrated by both color Doppler tissue imaging and recently by two-dimensional speckle-tracking echocardiography.
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