Sentence examples for mutations with effect from inspiring English sources

Combining the effective population size N e with U sdm, the genomic rate of the origin of slightly deleterious mutations with effect s, allows us to compute T cl, the average effective time between two clicks of Muller's ratchet in generations that are assumed to be discrete.

This finding suggests that deleterious mutations with effect sizes greater than the mean would not have accumulated very efficiently.

Furthermore, the 'selective sieve' (Morgan 2001) that is present during mitotic cell divisions will preferentially allow recessive alleles with large effect on zygotes or seeds to pass on while eliminating deleterious dominant mutations with effect on mature cell lines.

Multiplying by the rate of mutations with effect α [ i.e., Θ p ], the distribution of adaptive substitutions from standing genetic variation is given by p SGV ≈ Θ p Π seg ∫ 0 α max Θ p Π seg d α = C 1 p Π seg, (19 where C 1 is a normalization constant [black line in Figure 3, Figure 4, Figure 5, and Figure S3_2 and Figure S3_3 (File S3)].

However, even at low effective population size (N e = 7.5), mutations with effects on the order of the reciprocal of the effective size will be selected.

This sacrificed statistical power for any mutations with effects confounded with the population structure in this study.

Purifying selection is weaker for mutations with effects that are only mildly deleterious.

However, because the vast majority of mutations with effects on fitness are deleterious, special conditions are required for positive selection to promote increases in the mutation rate.

Did it involve the rapid fixation of one or more mutations with effects of a magnitude similar to the p.D273RfsX13 MSTN mutation?

Instead, under these conditions, selection for increased survival on Bt plants typically favors single mutations with effects large enough to boost survival on Bt plants (Fig. 1A).

Mutations with effects σ > σ ˜ have a fixation rate significantly above the neutral rate and, hence, account for most of the fitness flux.