Sentence examples for mutations while in from inspiring English sources

The major subgroup of tumor cells was characterized by a high frequency of APC and TP53 mutations while in the minor subgroup, mutations in the cell division cycle 27 (CDC27) and polyadenylate-binding protein, cytoplasmic, 1 (PABPC1) genes were predominant.

However, an important difference between glycolysis in activated T cells and cancer cells is that, in cancer cells, this metabolic program is a consequence of cellular dysregulation due to oncogenic mutations, while in T cells glycolysis represents a physiologically regulated metabolic adaptation [9, 11].

In adult AML, ITDs comprise the majority of mutations, while in pediatric AML, ITD mutations are less common.

In the MA lines SNMs represent 46.9% of the observed mutations, while in the ancestor they are significantly less common.

Without considering the GMS, an analysis may falsely conclude that certain regions of the genome do not undergo mutations, while in fact through an unavoidable limitation of the resequencing method, the experiments have no power to measure those variations.

However, in Drake's study, most spontaneous events used to determine the global rate are of local nature (indels, small rearrangements and point mutations), while in our study, the critical rates are the rates of chromosomal rearrangements.

Thus, it has been proposed that PolZeta can introduce mutations while filling in 3′ recessed termini during V(D J recombination, thereby allowing ligation of the two free ends by NHEJ (Zan et al. 2001).

Murray and colleagues initially demonstrated that the distribution of mutations in IRF6 was non-random; for example, protein truncation mutations, while common in VWS, were rare in PPS (8).

The NCBI collection of avian sequences had 2 out of 5991 (0.03%) mutants with more than a single mutation, while in the Ottenby collection the same type of mutants was found in 4 out of 230 (1.74%) isolates.

S320A, being refractory to phosphorylation, would function as a null mutation while in S320D the negative charge of the carboxyl side chain of aspartate might mimic that of the phosphoserine.

BCR/ABL translocation was detected in two patients positive for FLT3/ITD mutation while in one patient with NPM1 mutation.