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Exact(14)
Mutations were predominantly located within the cadherin domains.
Mutations were predominantly found in young patients (age ≤ 56 years) with higher KPS (>70).
BRAF mutations were predominantly found in two small regions of the kinase domain of the BRAF molecule.
In this tumor type, we found that mutations were predominantly in the CD24+ cells, rather than the CD24− cells.
Missense mutations were predominantly N-terminal but did not localize to a common functional domain (Fig. 1).
EGFR mutations were predominantly found in female subjects, nonsmokers, adenocarcinomas, and Japanese patients (for review, see Mitsudomi et al, 2006).
Similar(46)
EGFR and KRAS mutations are predominantly mutually exclusive with very rare tumours containing both genes mutated [ 44, 51].
All of these mutations are predominantly found in tumors with adenocarcinoma histology.
Although such mutations are predominantly somatic, a family with a germline T790M mutation has also been described [11].
Deregulation of signal transduction pathways mutations is found both in low- and high-grade gliomas, whereas other mutations are predominantly found in one or another group of gliomas.
Although LRRK2 mutations are predominantly associated with Lewy body pathology in PD brains [44] [45], some LRRK2 mutations produce nigral degeneration without additional pathology [41] suggesting that protein aggregation may not be an absolute requirement for mutant LRRK2-induced neurodegeneration.
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