Sentence examples for mutations were largely from inspiring English sources

These mutations were largely responsible for the lack of significant Expect scores associated with the pfam protein domain analysis.

These somatic mutations were largely missense, and in many cases, ATM behaved like a tumor suppressor [ 221].

Mutations were largely scattered along the length of the receptors, with one exception: a frame shift alteration in NOTCH3 clustered at amino acid position 1802.

These parallel mutations were, largely, associated with periods of rapid fitness change, indicating that there are major limitations on evolutionary pathways during antigenic change.

Previous estimates of the carrier frequency of mtDNA mutations were largely based on the ascertainment of pedigrees through one or more clinically affected individuals, followed by careful family tracing of the maternal lineage.

At that time, the population came closest to a purifying sweep with the major type close to 100% abundance; nevertheless the minority types carrying hfq, asm, and ribD mutations were largely unaffected at days 56 60.

We discovered that BAP1 is mutated in about 15% of clear-cell renal-cell carcinoma, and that BAP1 and PBRM1 mutations are largely mutually exclusive.

Nav1.2 mutations are largely associated with various epilepsy diseases, including BFIS3 (seizures, benign familial infantile 3), EIEE11 (epileptic encephalopathy, early infantile, 11), and DS (Fig. 3B and Table 3).

Although the mechanisms for these pleiotropic effects of IN mutations are largely unknown, there has been accumulating evidence for the involvement of retroviral INs in the reverse transcription [11], [13], [14], [18], [19].

In mammals, synonymous mutations are largely neutral, though they may sometimes experience weak selection [ 1].

In fact mitochondrial mutations are largely involved in various diseases, aging and cancer [ 12].