mutations were localized

USAGE SUMMARY

The phrase "mutations were localized" is correct and usable in written English.
It can be used in scientific or medical contexts to describe the specific areas or regions where mutations occur within a genome or organism. Example: "In our study, we found that the mutations were localized to the coding regions of the gene, which may affect its function."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

14 human-written examples

Again, the majority of mutations were localized to exons 5-8, the mutational hot-spot for p53 found in most cancers.

Breast Cancer Research

These mutations were localized near the conserved histidine motifs, which were proposed for binding iron required for enzymatic activity.

Metabolic Engineering

Seven of these mutations were localized in the DBD, i.e. the adRP-linked p.G56R mutation and the ESCS-linked p.R76Q, p.R76W, p.G88W, p.R97H, p.R104Q and p.R104W mutations.

Plosone

Of note, the Y15A and K186Q mutations were localized predominantly in cytoplasm (data not shown) and exhibited a low level of expression compared with WT-IN (Figure S1).

Plosone

Interestingly, IN-V5 protein with the Y15A or K186Q mutations were localized predominantly in cytoplasm (data not shown) and exhibited a low level of expression compared with WT-IN (Figure S1A).

Plosone

Notably, all tumors carrying SETD2 mutations were localized in the cerebral hemispheres (P = 0.0055).

Acta Neuropathologica

Human-verified similar examples from authoritative sources

Similar Expressions

46 human-written examples

Of particular importance to this study are the genes p53 and K- ras2 since a significant proportion of the mutations are localized to a relatively small number of mutational hotspots [ 13- 16].

BMC Biotechnology

Strikingly, these mutations are localized to peptide regions involved in interdomain and interprotomer interactions within the recombination complex.

Journal of Molecular Biology

Group selection is hard to explain by appeal to biological evolution, because genetic mutations are localized to individuals, and are thus unlikely to result in whole groups having different traits, but conformity allows for spread within a group, and thus overcomes this limitation of genes.

SEP

In the case of t-AML, the various point mutations are localized at the N-terminal, the DNA binding site [68].

Plosone

Since these mutations are localized in the common region between p19 and p21, we also investigated the effect of these mutations on p19-RACK1 binding using yeast two-hybrid assays.

Plosone

Expert writing Tips

Best practice

When describing the location of mutations, be specific about the genomic region (e.g., exons, introns, regulatory sequences) or the affected protein domain.

Common error

Avoid generalizations like "mutations were localized in the gene" without specifying the exact region or functional domain within the gene. Precision enhances clarity and impact.

Linguistic Context

The phrase "mutations were localized" functions as a statement indicating the identified position or region where genetic mutations have been found. This is a descriptive function crucial in scientific and medical contexts. As Ludwig AI confirms, this phrase is correct and usable in written English.

Expression frequency: Uncommon

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

In summary, the phrase "mutations were localized" is a grammatically correct and scientifically relevant expression used to specify the location of genetic mutations. As indicated by Ludwig AI, this phrase is suitable for formal scientific writing. It is most frequently found in scientific contexts, particularly in academic research related to genetics, oncology, and molecular biology. Alternative phrases such as "mutations were identified" or "mutations were mapped" can be used depending on the desired level of detail. When using this phrase, specificity regarding the location is crucial for clarity and impact.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

mutations were situated

Replaces 'localized' with 'situated', focusing on the placement of the mutations.

mutations were positioned

Similar to 'situated', emphasizing the specific location of the mutations.

mutations resided

Uses 'resided' to indicate where the mutations exist or are present.

mutations were pinpointed

Emphasizes the precision with which the locations of the mutations were determined.

mutations were mapped

Implies a more detailed and precise determination of the mutations' locations.

mutations were identified

Shifts the focus to the discovery rather than the location of the mutations.

mutations were concentrated

Indicates that the mutations were found more densely in a specific area.

mutations clustered

Similar to 'concentrated', suggesting a grouping of mutations in a particular region.

mutations were found

A simpler, more general way to state that the mutations were discovered in a particular area.

mutations were detected

Focuses on the detection of mutations, rather than their precise location.

FAQs

How can I use "mutations were localized" in a scientific paper?

In scientific writing, "mutations were localized" is used to specify the region where mutations are found. For example, "The "mutations were localized" to the active site of the enzyme, suggesting a direct impact on its function."

What does it mean when mutations are described as "localized"?

When mutations are "localized", it means their position or region of occurrence has been identified. This is crucial for understanding their potential effects on gene function or protein structure.

What are some alternatives to "mutations were localized" that I can use in my writing?

You can use alternatives like "mutations were situated", "mutations were mapped", or "mutations were found" depending on the specific context and the level of detail you want to convey.

Why is it important to know where mutations are localized?

Knowing where "mutations are localized" helps researchers understand the potential impact of those mutations on gene expression, protein function, and ultimately, the phenotype of the organism.