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This feature of the landscape may be part of the physical basis for the threshold robustness (tolerance) to mutations that was observed in other proteins [74], [75].
This is the only tumor type for any of the four knock-in mutations that was consistently observed on both backgrounds.
Interestingly, the one subject that underwent a second cycle of therapy after an 9-day interruption, rebounded to approximately the same 20% increase in private mutations that was observed during his first course of therapy.
For both datasets separate optimization of transition / transversion ratios represented an additional parameter applied to mutations that was incorporated into the modelling process.
Finally, we investigated one cell line with PDP1 mutations that was found to respond to phenylbutyrate (cell line 36, Table 1; Fig. 3A).
As presented above, the developers of MutationFinder made available a data set (http://mutationfinder.sourceforge.net) of 305 abstracts annotated with point mutations that was used for system development and 508 abstracts available for evaluation.
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In some passerine bird species, differing mutations that are not clearly related suggest the likelihood of multiple mutational events.
The IDH-2 mutation is just one of many enzyme mutations that are found in acute myelogenous leukemia.
They discovered five additional mutations that were crucial to the transition.
These are random changes, called de novo mutations, that are not inherited.
Researchers must still screen thousands of plants, just as natural breeders do, looking for mutations that are beneficial to farmers.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com