Sentence examples for mutations localize to from inspiring English sources

Note in Table 3 that these seven mutations localize to exons 5, 6, and 7 near the N-terminus of the protein, again consistent with the position of the ol sublocus in Grace's map.

The majority of activity-enhancing mutations localize to areas adjacent to hydrophobic patches.

Almost all Bin2.1 gain of function mutations localize to this motif [ 13, 15, 19].

In addition, more than half of Sacy mutations localize to LGI and thus the documented incompatibility between Bristol and Hawaiian strains caused by the peel-1 / zeel-1 system (Seidel et al. 2008) might have distorted the mapping results.

With few exceptions, dominant resistance mutations that reduce a drug's binding affinity localize to the drug's binding site or its immediate vicinity; confidence in this interpretation is especially high when multiple resistance mutations localize to the same site (Campbell et al., 2001; Shah et al., 2002; Wacker et al., 2012), although remote allosteric effects on drug binding are also possible.

Interestingly, all mutations localized to the LBD of the ER.

Fused in sarcoma (FUS) protein carrying ALS-associated mutations localizes to stress granules and causes their coalescence into larger aggregates.

The secondary screen revealed nine additional nonsynonymous somatic mutations localizing to the catalytic and non-catalytic domains of the encoded proteins.

Some disease state mutations localized to the Ubl domain have been shown to decrease the stability of the full-length parkin protein in vivo, although conflicting evidence has been presented for the effects of the mutations on E3 ligase activity.

FAD mutations localized to the central hydrophobic core of Aβ peptides [Dutch (E22Q), Flemish (A21G), Italian (E22K), Arctic (E22G) and Iowa (D23N)] enhance toxicity and aggregation propensity of the amyloidogenic peptides (Kumar-Singh et al, 2002; Murakami et al, 2002; Nilsberth et al, 2001; Van Broeckhoven et al, 1990; Van Nostrand et al, 2001).

It remains to be elucidated whether the NKX2.1 mutation localizes to the nucleus.