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Taken together, the data indicate that variable glycosylation does not affect the subcellular localization of ICAM-2 and that variants localize to the plasma membrane similar to the endogenous protein.
However, since both variants localize to the same regions, it stands that H2A.Z-1 would also be mainly present in euchromatic regions.
10.7554/eLife.05597.006 Figure 3. Endogenous and expressed GTP-Rab26 variants localize to a subset of synaptic vesicles in cultured hippocampal neurons.
Data in Figures 2F, 2G, and 2H indicate that ICAM WT and variants localize to cell membranes.
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We further examined 22 variants found in RAS family genes and 135 variants localized to exons encoding the kinase domain of respective proteins.
(E ) Quantification of mCherry-p62 variants localizing to BFP-ubiquitin-coated beads in mCherry-p62 and GFP-LC3B co-expressing cells.
We showed that an excess of derived high-frequency variants localized to mir-64c, and that mir-64c homologs are the only members of this cluster to have substitutions in the mature miR between C. remanei and C. latens.
The picture that has emerged is that individual PDE4 variants localized to discreet microdomains of cAMP signaling control the activity of individual proteins such as βARs, Cav1.2, RyR2, and PLB/SERCA within these domains [ 35, 39, 41, 58, 63, 84].
We found that the ACSL4_v1 variant localized to the inner side of the plasma membrane including microvilli, and was also present in the cytosol.
For example two splice variants of subunit a1 are expressed in rat neurons: one variant localized to axonal varicosities while the other was sorted to distal dendrites and axons [17].
Merged images (right) show that WT, V443I, and K614E OCA2 variants localize primarily to TYRP1-positive compartmentscaleale bar = 10 μm).
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