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Exact(21)
For a cell to become cancerous, a number of genetic mutations have to take place.
Whereas a large fraction of these analyzes can be performed in cell cultures in vitro, in many cases the consequences of the mutations have to be assessed in the context of an intact organism, as this is the context in which the Mendelian selection process of the tumorigenic process took place and the advantages of particular mutations become apparent.
A number of different mutations have to happen before the cell becomes a cancer cell.
Moreover, these mutations have to be located in the two elementary motifs that are interconnected by a loop.
Therefore, fairly radical mutations have to be applied in order to extinguish the biotin-binding activity of (strept avidin as previously reviewed [2].
Moreover, the problem that in order to explain the compatibility types, very specific and thus rare mutations have to occur repeatedly, does not manifest in the goalkeeper-model.
Similar(39)
If a sequence had more than one mutation, all mutations had to pass above threshold.
Whether BRAF inhibitors have the same effectiveness in patients with rare BRAF mutations has to be evaluated.
The proband inherited the frameshift mutation p.Val1105ArgfsX4 from his affected father and the missense mutation p.Thr2250Met from his mother, so the mutations had to be in trans-position.
And besides, what does cross species genetic-mutation have to do with guns anyway?
The precise contribution of a specific mutation has to be analyzed in patient samples [12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com