Sentence examples for mutations in molecular from inspiring English sources

As a game designed to simulate the role of mutations in molecular evolution, ACAGATATA makes a number of assertions.

The results show that the combination of homology modeling and molecular docking is a feasible method to filter inappropriate mutations in molecular design and point out beneficial mutations.

Although genetic and genomic tools have greatly furthered our understanding of resistance-associated mutations in molecular target sites of insecticides, the genomic basis of transcriptional regulation of detoxification loci in insect pests and vectors remains relatively unexplored.

Kimura (1985) introduced a two-locus model of compensatory neutral mutations in molecular evolution (fig. 1 a ).

Since then, other mutations in molecular pathways such as DNA mismatch repair (MMR) [ 3] and PTEN [ 4] have shown to result in syndromes causing endometrial carcinomas, the most common gynecological carcinoma to afflict women worldwide [ 5].

Moreover, an unknown number of mutations identified in molecular diagnostic environments where publishing is not a priority never reaches the public domain.

Major scientific reasons for repeated failures of such therapeutic approaches are attributed to reductionist approaches to research and infinite numbers of genetic mutations in chaotic molecular environment of solid tumors that are bases of drug development.

In most cases, the precise roles of these mutations in the molecular pathogenesis of FIP have not been tested experimentally in the natural host, mainly due to the lack of suitable experimental tools including genetically engineered virus mutants.

Much larger studies will be needed to address the predictive value of PIK3CA mutations in different molecular subsets of breast cancer in the context of different chemotherapies.

These diseases, as well as those associated with loss of function mutations in the molecular constituents of the ribosome, are termed ribosomopathies (reviewed in [ 20, 176]).

Depletion or mutations in the molecular players of the ESCRT complexes severely affects the structure and function of endo-lysosomal compartments.