Sentence examples for mutations in loop from inspiring English sources

Here we determined kinetic and structural properties of POP with mutations in loop A, loop B, and in two additional flexible loops (the catalytic His loop, propeller Asp/Glu loop).

Engineered point mutations in loop 1 (E409K and G410K) are shown to destabilise the dimer interface, lead to a higher proportion of the bound monomer and, in NF-κB luciferase reporter assays, are associated with reduced NF-κB activity compared with wt-p62.

The Vλ VI proteins accumulate non-conservative mutations in loop C–C' (part of CDR2) with 83% of patients with mutations in this region and presenting an absence of non-conservative mutations in loop A B and loop D E (structural representation of differences in Vλ is shown in Figure 4).

Mutations in loop 3 severely compromise the GlpG activity, suggesting the interaction between the substrate and loop 3 is functionally important (Baker and Urban, 2012).

(D ) Different combinations of remote mutations in loop 3 resulted in identical positioning of Leu 106, Trp 131, and Leu 132 in wt PTE and neo PTE (see also Figure 2 figure supplement 1C ).

In the present study, the presence of TP53 mutations in loop 2 and loop 3 did not seem to influence the disease-free survival on early-stage disease, although a 17% difference in the 3-year survival rate was seen.

(E ) Rewiring the interaction network in neo PTE by remote mutations in loops 4 and 5 led to β-metal displacement (see also Figure 2 figure supplement 1D ).

Fourth, the distance between the two active site zinc ions decreased from 3.8 to 3.3 Å in the forward evolution through displacement of the metal-chelating His201 and the β-metal, which was likely triggered by the combined action of several remote mutations in loops 4 and 5 (t172I, q180H, t199I, and a204G, Figure 2).

POP lacking loop A proved to be an inefficient enzyme, as did POP with a mutation in loop B (T590C).

The T590C mutation in loop B increased the preference for shorter peptides, indicating a role in substrate gating.

Most mutations occurred in loop regions.