Sentence examples for mutations in adjacent from inspiring English sources

Mutations in adjacent nucleotides in [ 9] were combined into one because aCGH reports mutations in adjacent positions as a single mutation.

Changes in the intron structure can induce mutations in adjacent exons, forming either SCs or non-synonymous codons that lead to a bias towards lower GC content [ 18].

The functional importance of this domain in peripheral neuron integrity is further underlined by the identification of mutations in adjacent amino acids (Lys157Asn and Asn161Thr) in patients with CMT2B (Houlden et al., 2004 b ; Meggouh et al., 2006).

We also noticed that FusAP610L grew much better than FusAA608E in 8-kan (Fig.  5A), despite the two being obtained from the same culture conditions and carrying mutations in adjacent residues.

As it has been suggested that local normal remnants of a field may develop into cancer after removal of the primary tumour site, further investigation is warranted to examine whether D310 mutations in adjacent normal tissue is associated with tumour recurrence.

In the case of several HIV epitopes linked to protective alleles, compensatory mutations arise in adjacent regions of the genome and their function is primarily to restore fitness capacity. 10 20 24 In HCV infection, the protective allele HLA-B*27 has been linked to a dominant CD8 T cell response associated with the NS5B 2841–49 ARMILMTHF epitope.

There is also the concepts of immunological "original sin" and altered epitope ligands where mutations in or adjacent to T cell epitopes preserve binding to MHC molecules but present an altered surface to the original T cell antigen receptor, resulting in an impaired or modified T cell response, including T cell immunosuppression [31] [37].

Intragenic revertants bn2bn39 -T444M, bn2bn40 -P443L, and bn2oz283 -E436K, are missense mutations in the adjacent editing domain.

Only one other study has identified mutations in LS adjacent to SCC and this was in only one case (Milde-Langosch et al, 1995).

The RIP process detects duplicated DNA sequences and introduces C-to-T mutations in cytosines adjacent to particular nucleotides (i.e., RIP target sites).

Although, it probably depends from genes to genes, we instead favor the hypothesis that the non-sense mutation was acquired by the ancestor and spread to the progeny with acquisition of subsequent mutations in the adjacent region.