Sentence examples for mutations implies that from inspiring English sources

Clinical phenotypes associated with different genetic mutations show some distinctive characteristics, but the heterogeneity between and among families carrying the same mutations implies that ALS manifestation is influenced by other genetic and nongenetic factors.

The absence of back mutations implies that mLLC increases over time, hence the accumulation of deleterious mutations (Haigh 1978).

The lethality of these mutations implies that this highly conserved domain has an essential role; hence its name CES.

Furthermore, no amino acid substitution at the 27 functionally essential positions and the absence of large deletions or frameshift mutations implies that these genes are functional.

The excess of short deletion over short insertion mutations implies that indel mutations of these lengths should lead to a loss of approximately 0.30 nt per single-nucleotide replacement.

In conclusion, the presence of a different spectrum of secondary rifabutin mutations implies that either, the mutation rate of individual mutations has changed, due to a defect in DNA repair or replication, or that additional spontaneous mutations are viable (and lead to resistance) in the presence of the S522L mutation [ 2].

CaM-binding/resultant nuclear accumulation was the only property of SRY found to be impaired by two of the CaM-NLS mutations, implying that inhibition of CaM-dependent nuclear import is the basis of sex reversal in these cases.

Inactivation is frequently seen in cases with p53 mutation, implying that loss of p14ARF expression is not functionally equivalent to mutation of p53.

Most other transformants contained additional frameshift or scrambled sequence mutations, implying that most iron binding pocket changes were deleterious or lethal.

The proportionately higher number of SCR-15/17 SCR-15/17 imutationsat SCR-15/17 may be functimplied significanthatven SCR-15/17 SCR-15/17t contain reported ligand-binding sites.

Interestingly, a similar proportion of naevi also contain BRAF mutations, implying that these alone are not sufficient for malignant transformation [73].