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Our observation that some of the knockdown fry exhibited more severe and earlier onset dilation of the renal tubules than pc mutants implies that the mutation in pc mutants may be a hypomorphic allele.
The lethality of Inv priA mutants implies that in Inv cells replication forks are arrested and disassembled.
The finding that DNA-RNA hybrids accumulate in S phase in sen1 mutants implies that the DNA-RNA hybrid has to face an incoming fork.
The relationship of body weight to litter size for mutants implies that group 2 animals would not occur in large litters owing to a competitive disadvantage.
However, the comparison of vascular defects in full NRP1 knockouts and Nrp1 cytoΔ /Δ mutants implies that the essential angiogenic function of NRP1 involves its extracellular, rather than intracellular, domain.
As predicted, anti-PR8 VLRBs could easily distinguish antigenic drift in H1N1 isolates from the 1940s and 1950s (Table 1 and Table 1 source data 2).> -wrap-foot> The loss of lamprey VLRB and mouse Ig binding in similar proportions to the PR8 HA-head domain mutants implies that each recognizes similar epitopes and is subject to similar physicochemical rules of binding.
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Such residual co-localization was evident even for the ire1 ΔKR/Δ-box) mutant, ire1 ΔKR/Δ-box3′ BE-mutanted targetimplyingrs irrespecthat of any cytosolic portion of Ire1.
A phosphopeptide mapping of these two mutants revealed that Ser was not phosphorylated in the Ser343Ala mutant, whereas Ser was normally phosphorylated in the Ser358Ala mutant, implying that Ser is required for Ser phosphorylation and that Ser is the site directly mediating 14-3-3 14-3-3 14-3-3
The lack of an obvious difference between the different truncation mutants implied that this phenotype was due to disruption of the acidic cluster at the very C-terminus of the gM cytoplasmic tail (Fig. 1A).
The finding that one functional copy of either Jag1 or Dll1 is able to rescue the dI6 phenotype detected in Dll1f/f Jag1f/f NesCre embryos, together with our data showing that dI6 neurogenesis is not affected in either Dll1 or Jag1 single mutants, imply that both ligands are able to control the rate of dI6 neurogenesis.
mIPSC rate was unaffected in frm-3 mutants, implying that pre-synaptic GABA release was not significantly altered.
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