Sentence examples for mutations distant from from inspiring English sources

In addition, a therapeutic pressure can result in the emergence of resistance due to mutations distant from the target site [23], and the ability to rapidly gain deep coverage of the entire genome (Figure 3A) will thus generally aid studies of HIV evolution.

Also, intronic mutations distant from splice sites could affect splicing.

Mutations distant from the active and binding sites cause minimal damage to the protein structure and activity, consequently resulting in mild phenotypes.

P450s may be especially prone to this type of change, since their catalytic mechanism involves large substrate-induced conformational shifts [ 40] that can be modulated by mutations distant from the active site [ 32, 37, 41].

Future evolution studies will have to confirm whether this is a general evolutionary pathway for variants originating from the CBM4-2 scafford or if mutations distant from the binding-cleft also are, as they are for antibodies, capable of fine-tuning ligand-binder affinity.

By some manner mutations distant from the 90 93 loop, such as A4V [ 27], produce a structural change that causes amino acids 90 93 to adopt a conformation that enables the binding of C4F6 despite the lack of the favored A at position 93.

In conjunction with Kermekchiev et al., our results suggest a complex network of effects from polymerase conformation, primer template annealing, thermodynamic states, and temperature produced the cold-sensitive phenotype from a conservative mutation distant from the polymerase active site.

No clear mechanism exists to explain how mutations distant to selectivity filter affect the channel selectivity.

Structure analysis revealed that all the mutations are distant from the active center, which may be difficult to be identified by conventional rational design strategy.

Another possibility is that mutations quite distant from the coding sequence could be involved.

Kinetic and equilibrium unfolding experiments indicate that the VH mutation also affects VL unfolding, possibly by partially destabilizing the interface provided by VH, even though the mutation is distant from the interface.