Sentence examples for mutations far from from inspiring English sources

On the other hand, directed evolution of enzymes usually targets the entire protein and discovers beneficial mutations far from the substrate binding site.

Furthermore, when tested on mutations far from the splicing site, the prediction power of ESEfinder revealed a sensitivity lower than that recently reported [ 32].

But, at the same time, this haplotype H17 is only two mutations far from H20, characteristic of table grapes with large berries (orientalis morphotype).

To the best of our knowledge, this is the first report on the generation of functional promiscuity through single amino acid mutation far from the active site.

However, one issue needs to be highlighted in this regard – mutations far away from the binding site can potentially affect the shape and or binding affinity of the binding pocket.

As this mutation is far from the residues involved in CO2 binding (K125 and R104), the mechanism for the loss of CO2 sensitivity is unclear.

The evaluation of the in vitro capacity of the L75P variant to activate LCAT is far beyond the scope of the present paper; however, it is likely that the L75P apoA-I has impaired LCAT activation ability, despite the mutation being far from the apoA-I central region involved in LCAT activation.

We assumed that all mutants have unchanged quantum yields, which was justified by the localization of the mutations that are far from the residues involved in FMN binding.

Although the analytical validity of the test for each mutation included in panels offered by DTC genetic testing companies has likely been validated, the clinical validity (i.e. how consistently and accurately the test detects or predicts the intermediate or final outcomes of interest) of the panel of mutations may be far from 100%.

We reasoned that the PTC27 and PTC140 transcripts were not affected probably because the mutations are too far from the intron the PTC27 transcript is more affected than PTC140 most likely because it is more sensitive to splicing-independent NMD, like we have seen for mRNAs that have not undergone splicing.

We observe a minimum in the adaptation time at values of the mutation rate relatively far from the phenotypic error threshold.