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Microsatellite sites diverge rapidly due to their high mutation rate; however, point mutations accumulate more slowly.
Mutations accumulate more rapidly in the polymorphic population than in the monomorphic populations.
The faster-X theory assumes that beneficial recessive mutations accumulate more easily under haploidy.
Because selection eliminates mutations that disrupt P450 activity, mutations accumulate more slowly in the monomorphic and polymorphic populations.
For s n ¯ m LLC = 1, mutations accumulate more rapidly than when s n ¯ m LLC = 10.
Because mutations accumulate more rapidly in the polymorphic experiments than the monomorphic ones, we evolved the polymorphic population for 15 generations rather than 25. Figure 3 shows how mutations accumulated during the course of the neutral evolution experiments (full data are given in Table 2 and Additional file 2).
Similar(54)
Their involvementin disease was derived from size exclusion chromatography experiments showing that Aβ1-42 and Aβ1-40 E22Q (later called the 'Dutch' mutation), accumulate more protofibrils compared with wild-type Aβ1-40 [ 13], and they were found to inhibit memory formation in animals [ 11].
Therefore, natural selection drives the conservation of the dominantly expressed genes against functional mutations, whereas their paralogs accumulate more mutations and eventually become fractionated, resulting in a higher gene density in the dominant subgenome and lower gene density in the dominated subgenomes.
Mitochondrial DNA replicates frequently and independently of the cell cycle and mitochondrial DNA mutations tend to accumulate more than chromosomal DNA mutations because mitochondrial DNA lacks protective histones.
Mildly deleterious mutations are certain to accumulate more rapidly than strongly deleterious mutations and thus mutations should accumulate predominantly in genes underlying traits which no longer enhance fitness rather than in those which are important for fitness [ 12].
This finding makes sense because r is the mutation rate per site, and longer gene sequences accumulate more mutations and result in greater degrees of divergence between the genes involved in a WGD pair.
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